Association between the dietary inflammatory index and markers of endothelial and systemic inflammation in hemodialysis patients

Objectives The current survey aimed to investigate the link between energy-adjusted dietary inflammatory index (E-DII) and risk factors for CVD including markers of endothelial systemic inflammation in Iranian hemodialysis patients. Methods Patients on at least 6 months prior enrollment were considered eligible this cross-sectional study. usual intakes individuals examined through 4 non-consecutive days 2 dialysis non-dialysis using a 24-h recall approach calculate E-DII. Multiple linear regression analysis was utilized E-DII selected biomarkers oxidative stress high-sensitive C reactive protein (hs-CRP), serum intercellular adhesion molecule (sICAM), vascular cell (sVCAM), malondialdehyde, nitric oxide (NO), sE-selectin, endothelin-1, beta (β) 95% confidence interval (CI) reported. Value p < 0.05 statistically significant. Results Overall, 291 patients make up our study population. In crude model, score positively associated with higher sVCAM-1 (β = 177.39; CI: 60.51, 294.26; trend 0.003). Further adjustment potential confounders attenuated findings way that an increase 128.72 observed when increased from −2.68 −1.14 (95% 13.50, 243.94). After controlling confounders, sE-selectin highest category as compared lowest 4.11; 0.22, 8.00; 0.039). Conclusion present suggest adherence pro-inflammatory diet among is status evidenced by sE-selectin; however, bidirectionality may exist role residual should be taken into account. Therefore, more longitudinal investigations are needed elucidate